Its gorgeous! The cameo material is most likely either sardonyx or cornelian - the later is a lighter colour shell material (NOTE: Not the orange translucent hard-stone known as carnelian!) - more orange than brown and the most common. The other possibility is an imitation cameo - a replica cameo of this quality is still collectible - plastic is relatively modern, so if the material is shell or hard-stone we see a lovely example of Period Antique Cameo Jewelry.
If you examine the white shell material (the subject's profile) where it joins the orange material, can you see any tell signs of joins, clue, tiny fissures or minute flee bits of open space?) If it is an imitation the white profile will be clued on (this is not always easy to tell though - sometimes nearly impossible!)
Is that the closure we can see, in last photo at 2 o'clock? It looks very European.
Cannot see the hallmark but I am leaning towards German or Austrian.
Tell me about the pearls! Do you think they could be Natural Pearls?