That's sad:( Pearl threaders should be able to help here. Jewelers in your area might be able to point you in the right direction towards a pearl threaders in your area, or another idea, enquire at a gem club in your area. Pearls are gems, after all. Jewelers often contract related pearl repairs to pearl threaders, these are the people who will be able to provide information on the type of pearls in your necklace and the people also who can restring the necklace using well matched small pearl substitutes for your two missing small pearls. It should look as good as new when restrung. Cheers!